Fri Jul 15 2022

20 articles - From Friday Jul 08 2022 to Friday Jul 15 2022

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Guidelines

Guidelines, position statements, white papers, technical reviews, consensus statements, etc…

Pancreatology

Identification of high-risk germline variants for the development of pancreatic cancer: Common characteristics and potential guidance to screening guidelines.

Information from each study was analyzed to draw conclusions on these variants as well as their association with pancreatic cancer. Information from this review is intended to improve precision medicine and improve criteria for screening.

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Meta-analysis

meta-analyses and systematic reviews

Am J Clin Nutr

The effect of fiber supplementation on chronic constipation in adults: an updated systematic review and meta-analysis of randomized controlled trials.

Fiber supplementation is effective in improving constipation. Particularly, psyllium, doses above 10 g/d and treatment duration of at least 4 weeks appear optimal, though caution is needed when interpreting the results due to considerable heterogeneity. These findings provide promising evidence on the optimal type and regime of fiber supplementation, which could standardize recommendations to patients. Systematic review registration PROSPERO registration number CRD42020191404.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Calcium and magnesium in drinking water and risk of myocardial infarction and stroke - a population-based cohort study.

Drinking water with a high concentration of calcium and magnesium, particularly magnesium, may lower the risk of stroke in postmenopausal women.

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Prunes preserve hip bone mineral density in a 12-month randomized controlled trial in postmenopausal women: the Prune Study.

A 50 g daily dose of prunes can prevent loss of total hip BMD in postmenopausal females after six months, which persisted for 12-months. Given that there was high compliance and retention at the 50 g dosage over 12 months, we propose that the 50 g dose represents a valuable non-pharmacological treatment strategy that can be used to preserve hip BMD in postmenopausal females and possibly reduce hip fracture risk. Clinical Trials Registry Number NCT02822378.

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Seaweed proteins are nutritionally valuable components in the human diet.

Furthermore, seaweed proteins from different species have complementary EAA profiles and can be mixed to form protein blends that are nutritionally on-par with animal products such as milk and whey. Thus, seaweeds may be viable protein sources with a reduced footprint that provide beneficial ecosystem services.

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The Role of Sleep and Eating Patterns in Adiposity Gain among Preschool-Aged Children.

Shorter sleep duration and later meal timing are associated with adiposity gain in preschoolers.

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Pancreas

Benefit From Nonsurgical Treatment for Asymptomatic Pancreatolithiasis.

Nonsurgical treatment in asymptomatic pancreatolithiasis may preserve pancreatic exocrine function as well as in symptomatic pancreatolithiasis.

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Comparing Outcomes and Cost Between Pancreas Transplant and Standard of Care in Patients With Type 1 Diabetes.

Although there is no difference in survival for PTA compared with standard of care, PTA is a cost-saving therapy for type 1 diabetes.

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Development and Evaluation of a Nomogram to Predict the Eventual Severity of the First Episode of Acute Pancreatitis.

This nomogram may be an effective clinical tool for predicting the first episode of SAP.

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Hospital Trends of Acute Pancreatitis During the Coronavirus Disease 2019 Pandemic.

Fewer patients were admitted for AP during the pandemic, suggesting that patients with milder symptoms avoided hospital interaction. Practices followed during the pandemic, especially avoidance of hospitalization and improved efficiency of hospital management, may reduce the burden of pancreatitis care in the future.

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Long-Term Follow-Up and Immunomonitoring of Relapsing Type 1 Autoimmune Pancreatitis Treated With Rituximab.

Rituximab is an effective treatment for type 1 autoimmune pancreatitis that provides a rapid strong clinical, biological, and morphological response, which persists after discontinuation without any safety issues.

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Preoperative Predictive Features of Invasive Carcinoma Among Intraductal Papillary Mucinous Neoplasm of the Pancreas.

Enhancing MN greater than or equal to 13 mm, obstructive jaundice, and an abrupt change in the PD caliber were predictive factors for invasive carcinoma. Systematic lymph node dissection may be omitted when a high-risk patient has none of these factors.

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Prognostic Analysis of Distal Pancreatectomy for Pancreatic Body and/or Tail Cancer Involving the Portal Vein: Is Pancreatic Body and/or Tail Cancer Involving the Portal Vein Resectable?

Pancreatic body and/or tail cancer contact with PV =180° should be considered borderline resectable because of poor survival.

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Reduced Tripartite Motif-Containing Protein 29 Deteriorates the Severity of Severe Acute Pancreatitis.

Our study demonstrated that TRIM29 negatively regulated the severity of SAP by degrading STING at its downstream, suggesting that TRIM29 and STING might serve as therapeutic targets for SAP.

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Risk Factors for Delayed Gastric Emptying After Pancreaticoduodenectomy.

We demonstrated that implementation of the preoperative stent, pylorus resection, and diabetes mellitus are independent risk factors for DGE. Pylorus preservation should remain the standard of care in PD.

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The Association Between Opioid Use and Opioid Type and the Clinical Course and Outcomes of Acute Pancreatitis.

Mortality among acute pancreatitis patients did not differ significantly between patients receiving morphine, nonmorphine opioids, and nonopioids. However, morphine treatment was associated with higher rates of some serious adverse events.

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The Landscape of Acute Pancreatitis Trials Registered in ClinicalTrials.gov: A Cross-sectional Study.

Our results indicate that the research activity falls short of what is needed in terms of the burden of AP. The distribution of these AP-related studies by global regions indicates that there exists regional disparities.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Pancreatology

Ecoevolutionary biology of pancreatic ductal adenocarcinoma.

Better understanding the disease through this lens can facilitate the development of novel therapeutic strategies to better control and cure PDAC. This review aims to integrate the current understanding of PDAC pathobiology into an ecoevolutionary framework.

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Letters&Replies

Letters to the editors and authors’ replies


Others

all remaining publications eg case reports, images of the month, etc…

Am J Clin Nutr

ASN highlights the need for multiple methods within nutrition research to advance the field.

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Liver Transpl

AFP Slope >7.5 ng/ml over 3 Months Before Liver Transplantation for HCC Predicts Recurrence Even After Controlling for AFP at Liver Transplantation.

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